Summary Noninvasive 40-Hz light flicker to recruit microglia and reduce amyloid beta load - PubMed pubmed.ncbi.nlm.nih.gov
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USA.gov, HHS, NIH, and NLM offer services such as Careers, Accessibility, and Help, and provide resources such as social media accounts and the study "Noninvasive 40-Hz light flicker to recruit microglia and reduce amyloid beta load" on their website.
Key Points
- USA.gov, HHS, NIH, and NLM are government entities providing services such as Careers, Accessibility, and Help.
- Photobiomodulation and visual stimulation have been studied as potential treatments for cognitive decline and Alzheimer's Disease pathology.
- Li-Huei Tsai, Chinnakkaruppan Adaikkan, Hansruedi Mathys, John Tipton, Matthew K Attokaren, Fatema Abdurrob, J Miller Douglas and Anthony J Martorell conducted a study on the use of noninvasive 40-Hz light flicker to recruit microglia and reduce amyloid beta load.
- The study was published in Nat Protoc (2018 Aug;13(8):1850-1868).
- The study is available on PubMed (DOI: 10.1038/s41596-018-0021-x; PMID: 30072722).
- The website https://www.ncbi.nlm.nih.gov/pubmed/ is an official website of the United States government and is secure, encrypting any information provided.
Summaries
185 word summary
Research Support from Non-U.S. Gov't and N.I.H., Extramural is available in citation formats including MLA, APA, AMA, and Nature Publishing Group. HHS Vulnerability Disclosure, FOIA, and Web Policies can also be found on NLM's website based in Bethesda, MD 20894 and 8600 Rockville Pike. USA.gov, HHS, NIH, and NLM offer services such as Careers, Accessibility, and Help. Resources include social media accounts YouTube, Facebook, and Twitter, as well as GitHub, LinkedIn, NCBI, Disclaimer, Bookshelf, PMC, MeSH, NCBI Literature Resources, Citation Manager, Collections, My Bibliography, Nature Publishing Group, Full Text Sources, LinkOut, PubChem Compound (MeSH Keyword), Related information, and Search in MeSH and PubMed.
Photobiomodulation and visual stimulation have been studied as potential treatments for cognitive decline and Alzheimer's Disease pathology. Studies have shown that exposure to 40-Hz white-light flicker can reduce amyloid beta. This noninvasive approach is simpler and faster to implement than optogenetics but does not target specific cell types.
The study "Noninvasive 40-Hz light flicker to recruit microglia and reduce amyloid beta load" (DOI: 10.1038/s41596-018-0021-x; PMID: 30072722) is available on the U.S. government website https://www.ncbi.nlm.nih.gov/pubmed/. JavaScript must be enabled to access all features.
414 word summary
The U.S. government website https://www.ncbi.nlm.nih.gov/pubmed/ is secure and offers features such as Add to Collections, Email citation, Save citation to file, PMID, PubMed, Abstract, Format, and Display options. JavaScript must be enabled to access all features. The site can be used to access the study "Noninvasive 40-Hz light flicker to recruit microglia and reduce amyloid beta load" (DOI: 10.1038/s41596-018-0021-x; PMID: 30072722).
The study was published in Nat Protoc (2018 Aug;13(8):1850-1868) and affiliated with 7 Broad Institute of Harvard and MIT, 6 Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 5 Picower Institute for Learning and Memory, Massachusetts Institute of Technology, 4 Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, and 3 Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology. Li-Huei Tsai et al., led by Annabelle C Singer, conducted the study.
Photobiomodulation and visual stimulation have been studied as potential treatments for cognitive decline and Alzheimer's Disease pathology. Studies have shown that exposure to 40-Hz white-light flicker can reduce amyloid beta. This noninvasive approach is simpler and faster to implement than optogenetics but does not target specific cell types.
Examples of research articles are provided with their PMID numbers and relevant information. These include "Exercise with 40-Hz light flicker improves hippocampal insulin signaling in Alzheimer disease mice" (PMID: 35356135); "Far infrared light irradiation enhances Aβ clearance via increased exocytotic microglial ATP and ameliorates cognitive deficit in Alzheimer's disease-like mice" (PMID: 35701825); "State-dependent modulation of thalamocortical oscillations by gamma light flicker with different frequencies, intensities, and duty cycles" (PMID: 36081653); "Transcranial alternating current stimulation combined with sound stimulation improves the cognitive function of patients with Alzheimer's disease: A case report and literature review" (PMID: 36212652); and "Combined Effects of Transcranial Alternating Current Stimulation and Sound Stimulation on USA.gov, HHS, NIH, and NLM are government entities offering services such as Careers, Accessibility, and Help. Resources include social media accounts YouTube, Facebook, and Twitter, as well as GitHub, LinkedIn, NCBI, Disclaimer, Bookshelf, PMC, MeSH, NCBI Literature Resources, Citation Manager, Collections, My Bibliography, Nature Publishing Group, Full Text Sources, LinkOut, PubChem Compound (MeSH Keyword), Related information, and Search in MeSH and PubMed.
Citation formats include MLA, APA, AMA, and Nature Publishing Group. Additionally, scite Smart Citations and The Lens - Patent Citations are available. HHS Vulnerability Disclosure, FOIA, and Web Policies can also be found. NLM is based in Bethesda, MD 20894 and 8600 Rockville Pike.
Lastly, there is Research Support from Non-U.S. Gov't and N.I.H., Extramural.
551 word summary
USA.gov, HHS, NIH, and NLM are government entities providing services such as Careers, Accessibility, and Help. HHS Vulnerability Disclosure, FOIA, and Web Policies are also available. NLM is based in Bethesda, MD 20894 and 8600 Rockville Pike. It has social media accounts such as YouTube, Facebook, and Twitter. Additional resources include GitHub, LinkedIn, Facebook, Twitter, NCBI, Disclaimer, Bookshelf, PMC, MeSH, NCBI Literature Resources, Citation Manager, Collections, My Bibliography, Nature Publishing Group, Full Text Sources, LinkOut, PubChem Compound (MeSH Keyword), Related information, and Search in MeSH and PubMed. Citation formats include MLA, APA, AMA, and Nature Publishing Group. Additionally, scite Smart Citations and The Lens - Patent Citations are available. Lastly, there is Research Support from Non-U.S. Gov't and N.I.H., Extramural.
Examples of research articles are provided with their PMID numbers and relevant information. These include "Exercise with 40-Hz light flicker improves hippocampal insulin signaling in Alzheimer disease mice" (PMID: 35356135); "Far infrared light irradiation enhances Aβ clearance via increased exocytotic microglial ATP and ameliorates cognitive deficit in Alzheimer's disease-like mice" (PMID: 35701825); "State-dependent modulation of thalamocortical oscillations by gamma light flicker with different frequencies, intensities, and duty cycles" (PMID: 36081653); and "Transcranial alternating current stimulation combined with sound stimulation improves the cognitive function of patients with Alzheimer's disease: A case report and literature review" (PMID: 36212652). Lastly, there is a review article on "Combined Effects of Transcranial Alternating Current Stimulation and Sound Stimulation on Cognitive Function in Patients With Alzheimer's Disease" (PMID: 36447479). Photobiomodulation and visual stimulation have been studied as potential treatments for cognitive decline and Alzheimer's Disease pathology. Studies have shown that exposure to 40-Hz white-light flicker can reduce amyloid beta, a peptide thought to initiate neurotoxic events in Alzheimer's disease. This noninvasive approach to driving 40-Hz neural activity is simpler and faster to implement than optogenetics, but does not target specific cell types. The light-flicker system can be constructed in ~1 day, and the flicker manipulation and assessment can be completed in a few days depending on the experimental design. Li-Huei Tsai, Chinnakkaruppan Adaikkan, Hansruedi Mathys, John Tipton, Matthew K Attokaren, Fatema Abdurrob, J Miller Douglas and Anthony J Martorell, led by Annabelle C Singer, conducted a study on the use of noninvasive 40-Hz light flicker to recruit microglia and reduce amyloid beta load.
The study was published in Nat Protoc (2018 Aug;13(8):1850-1868) and affiliated with 7 Broad Institute of Harvard and MIT, 6 Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 5 Picower Institute for Learning and Memory, Massachusetts Institute of Technology, 4 Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, and 3 Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology.
The study is available on PubMed (DOI: 10.1038/s41596-018-0021-x; PMID: 30072722) and includes related information on substances, MeSH terms, publication types and similar articles. The website https://www.ncbi.nlm.nih.gov/pubmed/ is an official website of the United States government and is secure, encrypting any information provided. It offers features such as Add to Collections, Email citation, Save citation to file, PMID, PubMed, Abstract, Format, and Display options. Additionally, My Bibliography, Collections, Citation manager, Clipboard, Send to and Email are available. JavaScript must be enabled to take advantage of all features. The site can be used to access Noninvasive 40-Hz light flicker to recruit microglia and reduce amyloid beta load.