Summary Plants Used as Antihypertensive - PMC www.ncbi.nlm.nih.gov
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Various medicinal plants have been studied for their antihypertensive properties and offer a natural alternative to traditional medications, but it is important to consult with a healthcare provider before use.
Key Points
- Natural herbs and plants can be used as antihypertensives, along with lifestyle changes and exercise.
- Garlic, hawthorn, ginseng, and other medicinal herbs have been traditionally used to manage hypertension.
- Various plant extracts and compounds have been studied for their antihypertensive properties, including green tea, ginger, and hibiscus.
- Certain plants may offer a natural alternative to traditional antihypertensive medications, but it is important to consult with a healthcare provider before using them as a treatment option.
- More research is needed to determine the efficacy and safety of using natural remedies for hypertension management.
Summaries
249 word summary
Various scientific studies have explored the potential antihypertensive effects of plants such as garlic, hawthorn, and olive leaf extract. Other plants such as green tea, ginger, and turmeric have also been studied. Specific compounds found in plants, such as ginsenoside Rg3, have been found to have antihypertensive properties. The studies suggest that certain plant extracts could be used as alternative or complementary treatments for hypertension. Various plant extracts such as Coriandrum sativum, Coptis chinensis, Camellia sinensis, Crocus sativus, Crataegus, and coriander have been studied for their antihypertensive properties. These plants have potential as natural antihypertensive agents. Various medicinal plants, including HS, Nigella sativa, Panax ginseng, Crocus sativus, Crataegus spp., Camellia sinensis, and Allium sativum, have been studied for their antihypertensive properties. These plants offer a natural alternative to traditional antihypertensive medications, but it is important to consult with a healthcare provider before using them as a treatment option. The article highlights that the use of natural remedies can be a good substitute for synthetic drugs when combined with lifestyle changes and light exercise. The review provides an analysis of traditional utilization, phytochemical constituents, and pharmacological values of medicinal herbs used to manage hypertension, including garlic, hawthorn, and ginseng. The article also discusses the underlying mechanisms by which these plants may lower blood pressure, such as through vasodilation and inhibition of the renin-angiotensin system. The review emphasizes the potential benefits of using natural remedies for hypertension management as they have been used for millions of years with minimum side effects.
820 word summary
This article discusses the use of natural herbs and plants as antihypertensives. Hypertension is a serious medical condition that can lead to various diseases. The article highlights that the use of natural remedies can be a good substitute for synthetic drugs when combined with lifestyle changes and light exercise. The review provides an analysis of traditional utilization, phytochemical constituents, and pharmacological values of medicinal herbs used to manage hypertension, including garlic, hawthorn, and ginseng. The article also discusses the underlying mechanisms by which these plants may lower blood pressure, such as through vasodilation and inhibition of the renin-angiotensin system. The review emphasizes the potential benefits of using natural remedies for hypertension management as they have been used for millions of years with minimum side effects. The article concludes that factors like nitric oxide, cardiac output, and peripheral vascular resistance also play an important role in hypertension. This document provides details of traditional herbs with potential antihypertensive effects, including their mechanisms of action and antioxidant and anti-inflammatory properties. Plants such as Coptis chinensis, Camellia sinensis, and Allium sativum have been studied. Various assays on animal and human models were used to study plants with antihypertensive properties, such as Cirsium japonicum, Citrus limetta, and Valeriana wallichii. These plants offer a natural alternative to traditional antihypertensive medications, but it is important to consult with a healthcare provider before using them as a treatment option. Various medicinal plants have been studied in clinical trials for their antihypertensive properties, including HS, Nigella sativa, Panax ginseng, Crocus sativus, Crataegus spp., Camellia sinensis, and Allium sativum. Hibiscus sabdariffa (HS) is a plant used worldwide for medicinal purposes and has antihypertensive effects due to its active constituents cyanidin-3-sambubioside and delphinidin-3-sambubioside. Andrographis paniculata, garlic, B. pilosa, celery, and A. graveolens also have antihypertensive properties. Tea's major flavonoids catechins have vasodilating properties and can increase blood flow by decreasing oxidative stress and dimethylarginine. Bidens pilosa can decrease plasma creatinine levels, and quercetin can improve endothelium function and prevent hypertension through different mechanisms such as vasodilatation, lipid profile improvement, and free radical scavenging. These plants contain numerous useful chemical constituents and are used in folk medicines in various forms. Various plant extracts such as Coriandrum sativum, Coptis chinensis, Camellia sinensis, Crocus sativus, Crataegus, and coriander have been studied for their antihypertensive properties. Green tea has been associated with a lower risk of hypertension. Cymbopogon citrates and saffron can also reduce blood pressure through various mechanisms. Seed of Blessing (Nigella sativa), lemongrass oil, black seed extract, and black cumin also have antihypertensive effects and possess other pharmacological functions such as antioxidant, anti-inflammatory, antidiabetic, and myorelaxant effects. These plant extracts have potential as natural antihypertensive agents. Panax (ginseng) roots have hypotensive, antioxidation, and vasorelaxation effects. Ginsenoside Rg3 increases expression of eNOS, which leads to an increase in the production of NO followed by vasorelaxation. Danshen has anti-microbial, antiviral, anti-oxidant, anti-cancer, anti-inflammatory activity and cardiovascular disease treatment benefits. Ginger has multiple biological activities including blood pressure-lowering, antioxidant, cholesterol-lowering, anti-inflammatory, antimicrobial, anticancer, antiplatelet aggregation, hypoglycemic, cardiovascular protective, neuroprotective, respiratory protective, antidiabetic, chemopreventive, antiobesity, antiemetic, and antinausea effects. Rauwolfia serpentina, Gokhru, and Tribulus terrestris have been used for their antihypertensive properties. Plants such as Terminalia arjuna, neem, turmeric, garlic, hawthorn, and olive leaf have been studied for their potential antihypertensive effects. Studies suggest that these plants may modulate various parameters related to hypertension pathogenesis and improve cardiovascular health. Other plants studied include hibiscus, beetroot, ginger, and green tea. The studies vary in methodology and results, but overall suggest that these plants may have potential as natural remedies for hypertension. The text excerpt also includes lists of studies on plants used as antihypertensive agents with corresponding references and publication details. This summary presents various scientific studies on plants used as antihypertensive agents, published in different journals between 1992 and 2019. The studies cover a range of plant species, including ginseng, garlic, hawthorn, green tea, hibiscus, and others. Some studies focus on specific compounds found in plants that may have antihypertensive properties. The article provides references to specific studies on each plant and suggests that certain plant extracts could be used as alternative or complementary treatments for hypertension. Plants such as garlic, hawthorn, and olive leaf extract have been found to lower blood pressure, according to various studies listed in this article. Other plants such as green tea, ginger, and turmeric have also been studied for their effects on blood pressure. The article provides a list of references for each study mentioned, which cover a range of plant species and explore their potential effects on blood pressure. Some studies focus on specific compounds or extracts from the plants, while others examine the plants as a whole. The studies suggest that certain plants may have antihypertensive properties, but more research is needed to determine their efficacy and safety for human use. Overall, the studies suggest that these plants could be used as complementary or alternative therapies for hypertension management.
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This text excerpt contains a list of references to articles related to plants used as antihypertensives. The list includes authors, titles, and publication information for each article. This excerpt contains a list of references to studies on plants used as antihypertensive agents. The studies cover a range of plant species and explore their potential effects on blood pressure. Some of the studies focus on specific compounds or extracts from the plants, while others examine the plants as a whole. The references include both animal and human studies, and some have been conducted in vitro. Overall, the studies suggest that certain plants may have antihypertensive properties, but more research is needed to determine their efficacy and safety for human use. The article lists various studies on plants that have been used as antihypertensive agents. The studies include research on plants such as Allium sativum, Crataegus spp., Hibiscus sabdariffa, and Rauwolfia serpentina. Studies have shown that these plants can reduce blood pressure and have potential as alternative treatments for hypertension. Some of the studies also highlight the active compounds in these plants that contribute to their antihypertensive effects. Overall, the studies suggest that these plants could be used as complementary or alternative therapies for hypertension management. This is a list of references to studies on plants used as antihypertensive agents. The studies were published in various journals from 1984 to 2019 and cover a range of plant species and their effects on blood pressure. Some of the studies mention specific compounds found in the plants that may be responsible for their antihypertensive effects. Overall, the list provides a resource for researchers and practitioners interested in exploring natural remedies for hypertension. The article lists various studies on plants that have been used as antihypertensive agents. Studies have found that plants such as garlic, hawthorn, and olive leaf extract can help lower blood pressure. Other studies have looked at the effects of plants such as green tea, ginger, and turmeric on blood pressure. The article provides a list of references for each study mentioned. This text excerpt provides a list of references for studies on the use of plants as antihypertensive agents. The studies include experiments on various plants and their extracts, including those used in traditional medicine. The studies were conducted in different countries and published in various scientific journals between 2000 and 2011. Some of the key plants studied include Allium sativum, Hibiscus sabdariffa, and Rauwolfia serpentina. These studies suggest that certain plants and their extracts have potential as natural remedies for hypertension. This article lists various plants that have been studied for their potential antihypertensive effects. The plants include Carica papaya, Hibiscus sabdariffa, Zingiber officinale, Allium sativum, and many others. Studies have shown that these plants may help lower blood pressure levels and have other health benefits. The article provides references to specific studies on each plant. This excerpt lists various scientific studies published in journals such as Ecotoxicol. Environ. Saf., BMC Complement. Altern. Med., Phytother. Res., Food Chem. Toxicol., Cardiovasc. Drugs Ther., J. Sci. Food Agric., PLoS ONE, World J. Cardiol., J. Nutr. Biochem., Evid. Based Complement. Altern. Med., Nutr. Res., Diabetes, and J. Physiol. Pharmacol. that explore the use of different plants as antihypertensive agents. These studies suggest that certain plant extracts have potential antihypertensive properties and could be used as alternative or complementary treatments for hypertension. This excerpt lists various studies on plants that have antihypertensive properties. The studies include research on plants such as garlic, green tea, and hibiscus. The studies were conducted between 1992 and 2014 and were published in various journals. This excerpt is a list of references from a document about plants used as antihypertensive. The list includes various studies and articles that discuss the mechanisms and pathophysiology of hypertension, as well as different plant-based treatments. Some of the studies mentioned include those by Talaei et al., Potawale et al., and Kapoor et al. The list also includes articles from various journals such as J. Nutr. Food Secur., Evid. Based Complement Altern. Med., and Front. Pharmacol. The full article can be found at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7981375/. This excerpt contains a list of references to various studies on plants used as antihypertensives. The studies cover a range of plant species and their potential effects on blood pressure. Some studies focus on specific compounds found in plants that may have antihypertensive properties. These studies were conducted in various countries and published in different journals over several years. This excerpt lists various studies on the use of plants as antihypertensive agents. The studies are cited by number and include information such as the authors, year of publication, and journal. The plants mentioned include ginseng, garlic, hawthorn, and others. This is a list of studies on plants used as antihypertensives. The studies are numbered from 139 to 166 and are from various journals including J. Ethnopharmacol, Phytother. Res., and Phytomedicine. The studies cover a range of plants and their potential use as antihypertensives. This text excerpt lists various studies on plants used as antihypertensive agents. The studies are primarily sourced from PubMed and Google Scholar. The plants studied include Gasparotto, Lin S-Y, Kwan C-Y, Yeh C-T, Somova, Gilani, Maghrani, Bankar, Hernandez-Abreu, Zaoui, Bastos, Ahmad, Nguelefack-Mbuyo, Chiang YM, Xagorari, Mao Q-Q, Shin SG, Cho YH, Qian Q, Wang Y, and Ma L. The studies range from 2000 to 2019 and cover a variety of plants and their potential antihypertensive effects. This text excerpt lists various studies on plants used as antihypertensive agents, with corresponding references and publication details. The studies cover a range of plant species and their potential effects on blood pressure, including traditional medicinal plants and common food ingredients. The studies come from various countries and were published between 2005 and 2017. This excerpt lists various studies that have investigated the antihypertensive properties of different plants. The studies range from 2001 to 2019 and have been published in various journals, including J. Nutr. Biochem., Evid. Based Complement. Altern. Med., and J. Restor. Med. The plants studied include those such as Hibiscus sabdariffa, garlic, olive leaf, and green tea. The studies vary in their methodology and results, but overall suggest that these plants may have potential as natural remedies for hypertension. This is a list of studies that have investigated the use of plants for their antihypertensive effects. The studies are listed in descending order based on their reference number. The plants studied include a variety of herbs, fruits, and vegetables, such as garlic, ginger, hibiscus, and beetroot. The studies suggest that these plants may have potential as natural treatments for hypertension, but further research is needed to confirm their effectiveness and safety. This text excerpt lists various scientific studies on plants that have been used as antihypertensive agents. The studies range from 1984 to 2019 and cover a variety of plant species with potential health benefits. Some of the plants mentioned include neem, turmeric, garlic, hawthorn, and olive leaf. The studies highlight the potential of these plants to lower blood pressure and improve overall cardiovascular health. This text excerpt contains a list of references to studies on plants used as antihypertensive. The references are organized in descending order from most recent to oldest. Each reference includes the title, authors, and publication information. The summary does not include any of the email addresses or information about conflict of interest or ethical standards. This review discusses commonly used plants for managing and treating hypertension, highlighting their mechanisms of action. Natural plants and their isolates affect hypertension pathogenesis by modulating various parameters such as endothelial function, ROS production, pro-inflammatory signaling, platelet activation, ion channels, ACE inhibition, and gene expression. Herbal remedies possess a broad spectrum of achievement, but patients should be properly educated on their consumption. One unique medicinal plant currently used is Terminalia arjuna, which has mild diuretic, cardiotonic, anti-inflammatory, ROS scavenging, prostaglandin E2, antithrombotic, antiplatelet effects, anti-atherogenic effects, and hypolipidaemic action. Its various biological properties make it an effective cardioprotective agent. The decoction of arjuna bark is used in Indian subcontinental areas for the treatment of congestive heart failure, dyslipidemia, anginal pain, and hypertension. Plants such as Rauwolfia serpentina, Gokhru, and Tribulus terrestris have been used for their antihypertensive properties. R. serpentina contains indolealkaloids, including reserpine, which can reduce blood pressure by slowing down the nervous system. Gokhru has been found to possess an antihypertensive effect by membrane hyperpolarization and relaxation of arterial smooth muscle. Tribulus terrestris contains flavonoids, alkaloids, and glycosides that have immunomodulatory, anti-inflammatory, and antihypertensive properties. Ginger has also been shown to lower blood pressure in patients with type 2 diabetes when used daily for 56 days. Ginger, specifically the phenolic compounds shogaol and gingerols, has multiple biological activities including blood pressure-lowering, antioxidant, cholesterol-lowering, anti-inflammatory, antimicrobial, anticancer, antiplatelet aggregation, hypoglycemic, cardiovascular protective, neuroprotective, respiratory protective, antidiabetic, chemopreventive, antiobesity, antiemetic, and antinausea effects. Ginger oils are considered to be a fresh antagonist to the angiotensin II type 1 receptor to produce vasodilation. Intravenous and oral doses of (6)-shogoal and (6)-gingerol have been found to produce a significant decline in blood pressure. The aqueous extract of ginger can reduce ACE and lipid peroxidation.
Danshen, one of the oldest and regularly used traditional herbs of China generally utilized for CVDs treatment, has beneficial pharmacological behavior like anti-microbial, antiviral, anti-oxidant, anti-cancer, anti-inflammatory activity and cardiovascular diseases. Its major phytochemicals are danshensu, tanshinones (tanshinone I & tanshinone II) salvianolic acids (A & B) with other compounds as minor. It diminishes pulse rate and systolic blood pressure. Danshen also inhibits ACEs to cause a reduction in blood pressure. Danshen's metabolite increases stored as well as the influx of Ca2+, moderately via enhancing the synthesis of eNOS signaling and amplify NO production to produce vasodilation. Tanshinone IIA causes vasodilation without involvement of endothelium cells mechanism.
P. ginseng can cause a major decreasing effect in SBP and DBP in patients having gentle hypertension as well as healthy subjects. Ginsenoside Rg3 produces an increasing effect on expression of eNOS leads to an increase in the production of NO followed by vasorelaxation. Ginseng also inhibits adrenal catecholamines emission, which has an additional effect on antihypertensive character. It can also increase blood pressure to regularize hypotensive conditions rheostatically probably by alteration of vascular character, adjusting ANS, or adapting baroreflex of arteries. Ginseng can normalize hypertensive and hypotensive conditions. It also acts as an anti-carcinogenic and antidiabetic agent. Plants Used as Antihypertensive: - Panax (ginseng) roots have been used in folk medicine for centuries and have many biological benefits, including hypotensive, antioxidation, and vasorelaxation effects. The most active ginsenosides are Rb1, Rg1, Rg3, Rh1, Re, and Rd. - Black cumin has anti-inflammatory properties and can cause vasodilation by reducing the synthesis and release of COX-1 and COX-2 metabolites. Its oil inhibits reactive oxygen species and can help manage hypertension. - Regular use of black seed extract can significantly decrease blood pressure, possibly due to its bioactive components such as thymol, thymoquinone, thymohydroquinone, dithymoquinone, and -hederin. - Lemongrass oil can suppress ROS activity and reduce iNOS and NF-kB activity, producing anti-inflammatory actions. Citronellol, found in lemongrass, can block calcium channels and modify caffeine-gated and IP-dependent intracellular stores of Ca2+, leading to antihypertensive effects. - Seed of Blessing (Nigella sativa) has a broad range of pharmacological activities and is used to treat various ailments such as diabetes, inflammation, hypertension, cardiovascular complications, hepatic disorder, cancer, kidney disorder, and arthritis. The article discusses the use of various plant extracts as antihypertensive agents. One such plant is Cymbopogon citrates, which has been shown to reduce hypertension in rats induced by sucrose and ethanol. The major constituent of C. citrates is citral, which has vasorelaxant properties and inhibits the attenuation caused by L-NAME. Safranal, a constituent of saffron (Crocus sativus), can also reduce blood pressure through various mechanisms, such as potassium channel opening and b-adrenoceptor antagonism. Saffron extract contains crocin, safranal, picrocrocin, and crocetin, which act as antihypertensives through different mechanisms of action. Overall, these plant extracts have potential as natural antihypertensive agents. Plants such as Crocus sativus, Crataegus, and coriander have been used for their anti-hypertensive properties. Crocus sativus extract has been found to have anti-inflammatory action and can decrease levels of VCAM-1, IL-6, NF-kB, iNOS, and TNF-a. Crataegus extract can activate multiple signaling pathways and cause vasodilation by increasing phosphorylation and activation of eNOS at serine1177, resulting in the synthesis and release of NO in endothelial cells. Hawthorn extract is effective on both endothelial cells and VSMCs. Coriander extract has an inhibitory effect on NF-kB and iNOS and can produce a fall in mean arterial blood pressure, SBP, and DBP in a dose-dependent manner in normotensive Sprague Dawley rats. These plants have not been extensively tested in clinical trials for their effects on BP, but they possess other pharmacological functions such as antioxidant, anti-inflammatory, antidiabetic, and myorelaxant effects. Hawthorns shrubs are employed in conventional medicine for the handling of CVDs. Plants such as Coriandrum sativum, Coptis chinensis, and Camellia sinensis have been studied for their antihypertensive properties. Berberine, found in Coptis chinensis, has been shown to have a hypotensive effect by increasing the expression of eNOS and promoting vasodilation. Green tea has also been shown to reduce blood pressure through various mechanisms such as inhibiting angiotensin-converting enzyme and enhancing endothelial function. Regular consumption of green and black tea has been associated with a lower risk of hypertension. Each type of tea has different flavors and constituents depending on the process used. The article discusses the use of plants as antihypertensive agents. It highlights the potential benefits of tea, specifically its major flavonoids catechins, which have vasodilating properties and can increase blood flow by decreasing oxidative stress and dimethylarginine. Bidens pilosa is another plant that has been shown to have hypotensive effects and can decrease plasma creatinine levels. Quercetin, found in various plants, can also improve endothelium function and prevent hypertension through different mechanisms such as vasodilatation, lipid profile improvement, and free radical scavenging. These plants contain numerous useful chemical constituents and are used in folk medicines in various forms. Plants like B. pilosa, celery, and A. graveolens have been found to have antihypertensive properties. B. pilosa can treat hypertension associated with the liver and has flavonoids that reduce oxidative stress. Celery seeds have a hypotensive effect due to hydrophobic components like n-butylphthalide. A. graveolens has anti-inflammatory, anti-hypertensive, anti-microbial, anti-cancer, and anti-oxidant properties. The chloroform extract of Andrographis paniculata can activate NO synthesis and relax smooth muscles, and its extracts contain several diterpenoid compounds that inhibit the activity of - adrenoceptors, autonomic ganglion receptor and angiotensin converting enzyme (ACE). A. paniculata can also decrease BP by decreasing reactive oxygen species and ACE activities in impulsively hypertensive rats (SHR). Andrographis paniculata is a medicinal plant used in eastern and southeastern Asia to treat cold and fever. Garlic (Allium Sativum) is a multipurpose herb used for thousands of years worldwide as a vegetable and has pharmacological activities such as antihypertensive, antioxidant, anti-cancer, anti-inflammatory, antibacterial, and hypocholesterolemic. The bulb of Allium Sativum can be used in various forms such as raw, dried powder, aqueous extract, oil, and aged garlic extract (AGE). AGE produces a dependable lowering of blood pressure compared to other forms of Allium Sativum. The water-soluble active constituents of Hibiscus sabdariffa (HS), predominantly cyanidin-3-sambubioside and delphinidin-3-sambubioside, are responsible for the hypocholesterolemic, antioxidant, and antihypertensive effects. HS has antihypertensive and vasodilator effects in human and experimental animals and is used in different regions to treat hypertension. Hibiscus sabdariffa (HS) is a plant used worldwide for its pleasing taste, decorative appearance, and medicinal properties. Its various parts, including the flower, leaves, and calyx, are used for treating various medicinal problems in many West African countries. Nigerian citizens use calyx infusion (zobo) as an antihypertensive agent.
Clinical trials have been conducted on different medicinal plants as antihypertensive agents. These trials have shown that HS, Nigella sativa, Panax ginseng, Crocus sativus, Crataegus spp., Camellia sinensis, and Allium sativum can all help lower blood pressure. The trials varied in design, population size, condition, dose, and duration.
Overall, these medicinal plants offer a natural alternative to traditional antihypertensive medications. However, it is important to consult with a healthcare provider before using them as a treatment option. The following is a summary of plants used as antihypertensive agents, along with their specific effects:
- Salvia cinnabarina: antihypertensive through NE antagonism and nitric oxide production in male Wistar rats. - Jatropha gossypiifolia: reduced blood pressure through ACE inhibition in rats fed egg yolk. - Polyalthia longifolia: vasodilator through nitric oxide production in perfused kidney and aorta of rabbit. - Echinodorus grandiflorus: antihypertensive through calcium influx blocking in rat aorta. - Solanum torvum: antihypertensive through increased vitamin C utilization in hypertensive rats. - Melothria maderaspatana: antihypertensive through NO/cGMP overproduction in rat aortic rings. - Antrodia camphorata: antihypertensive through NO/cGMP overproduction in rats with NO synthesis inhibition. - Cudrania tricuspidata: antihypertensive through ACE inhibition in rat plasma. - Erythroxylum gonocladum: blood pressure lowering effect through channel activation in preparations of rabbit jejunum. - Valeriana wallichii: hypotensive through calcium inhibitor in rat aorta. - Averrhoa carambola: antihypertensive through ACE inhibition in anesthetized rats. - Achillea millefolium: blood pressure lowering effect through Ang II receptor blocker in mice. - Citrus limetta: antihypertensive through Ang II receptor blocker in hypertensive rats. - Astragalus complanatus: vasorelaxation through nitric oxide production enhancer in rat thoracic aorta. - Cirsium japonicum: hypotensive through mediating NO/cGMP production in rat thoracic aorta. - Geum japonicum: hypotensive through calcium antagonism in rats' hearts. - Eugenia uniflora: cardiotonic through Na,K-ATPase pump stimulator in rats' hearts. - Cecropia pachystachya: vasorelaxing through NO production enhancer in Wistar rat aorta. - Tanacetum vulgare: antihypertensive through ACE inhibitor in rat plasma. - Clerodendron trichotomum: hypotensive through mediating NO/c Plants with antihypertensive properties were studied using various assays on animal and human models. Cymbopogon citratus, Mammea africana, Bidens pilosa L, Zingiber officinale, Salviae miltiorrhizae, Panax spp., Hibiscus sabdariffa, Crocus sativus, Crataegus spp., and Coriandrum sativum were found to have vasorelaxant, antioxidant, anti-inflammatory, and anti-proliferative effects. These plants were shown to inhibit lipid peroxidation, decrease TNF- and IL-6 levels, reduce NF-B activation, enhance antioxidants, and activate eNOS. Some plants were also found to block Ca2+ channels and lower uric acid concentration. This document provides details of common traditional herbs with potential antihypertensive effects. The herbs have been shown to have various mechanisms of action, such as upregulating eNOS expression, decreasing EMP, inhibiting VCAM-1 and NF-B, increasing HO-1 enzyme, and blocking AT receptors. They also have antioxidant and anti-inflammatory properties. Some of the herbs that have been studied include Coptis chinensis, Camellia sinensis, Apium graveolens, Andrographis paniculata, and Allium sativum. The document also includes tables and figures explaining the mechanisms of action and the effect of reactive oxygen species on the blood vascular system. Hypertension is a critical health problem that can lead to cardiovascular diseases. The maintenance of physiological blood pressure levels involves a multifaceted relationship of diverse elements of an incorporated neurohumoral system. Any imbalance in components of this system can indirectly or directly cause an increase or decrease in the average blood pressure level, leading to damage of the target organ and cardiovascular diseases. Natural herbs and shrubs have been used to treat almost all ailments of the human body worldwide. This review provides a summary of the anti-hypertensive effects of natural herbs in animal studies and human involvement as well as the underlying mechanisms from the bottom of cell culture and ex-vivo tissue data. The type of phytochemical constituents present in any natural plant makes it useful to treat a particular ailment or group of ailments. The treatment with medicinal herbs/shrubs is essential and cheaper treatment with lesser rates of side effects as compared to allopathic treatment. Factors like Nitric oxide NO and cardiac output and peripheral vascular resistance also play an important role in hypertension. Hypertension is a serious medical condition that can increase the risk of heart, brain, kidney, and other diseases. It is predicted that by 2025, the rate of hypertension will increase by 60%. There are two types of hypertension: primary or essential hypertension and secondary hypertension. Synthetic drugs used to manage hypertension are associated with various side effects, making natural herbal drugs with potential antihypertensive activity a good substitute when combined with lifestyle changes and light exercise. Natural herbs and shrubs are widely used to treat almost all ailments of the human body. Medicines from natural plants are consumed by 80% of the world's population for major health concerns. This review provides an analysis of the traditional utilization, phytochemical constituents, and pharmacological values of medicinal herbs used to normalize hypertension. Herbal medicines have been used for millions of years for the management and treatment of hypertension with minimum side effects. The aim of this review is to collect information on the anti-hypertensive effects of natural herbs in animal studies and human involvement as well as to recapitulate the underlying mechanisms. This article discusses plants that are used as antihypertensive agents. It is licensed under a Creative Commons Attribution 4.0 International License and was published in Nat Prod Bioprospect in April 2021. The article provides information about the authors and their affiliations, but does not include any specific information about the plants themselves. The article discusses plants that have been used as antihypertensives. These plants have been used in traditional medicine for centuries and are still used today. Some of the plants mentioned include garlic, hawthorn, and ginseng. The article also discusses the mechanisms by which these plants may lower blood pressure, such as through vasodilation and inhibition of the renin-angiotensin system. Overall, the article highlights the potential benefits of using natural remedies for hypertension management.