Summary Multi-level analysis of the gut–brain axis shows autism spectrum disorder-associated molecular and microbial profiles | Nature Neuroscience www.nature.com
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The study examined the gut-brain connection and identified specific gut microbiota profiles associated with autism spectrum disorder.
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Key Points
- The gut-brain axis is implicated in autism spectrum disorder (ASD), but there is limited reproducibility across studies.
- Age and sex are significant confounders in ASD-specific microbiome differences.
- Microbial log ratios show a shift in microbial load between individuals with ASD and neurotypical controls.
- Longitudinal intervention studies show significant improvements in autism symptoms after fecal matter transplant treatment.
- Metabolic profiles from the microbiome and human transcriptome show a significant overlap in pathways expressed in the gut and brain in individuals with ASD.
Summaries
26 word summary
A study analyzed the gut-brain axis to identify profiles linked to autism spectrum disorder. It aimed to understand differences in gut microbiota in individuals with ASD.
41 word summary
A multi-level analysis of the gut-brain axis was conducted to identify molecular and microbial profiles associated with autism spectrum disorder (ASD). The study aimed to understand patient subgroups and differences in the gut microbiota composition and functionality in individuals with ASD.
828 word summary
A multi-level analysis of the gut-brain axis reveals molecular and microbial profiles associated with autism spectrum disorder (ASD). The study focuses on understanding patient subgroups and differences in the gut microbiota composition and functionality in individuals with ASD. It also explores
Autism spectrum disorder (ASD) is a neurodevelopmental disorder with cognitive, behavioral, and communication impairments. The gut-brain axis (GBA) has been implicated in ASD, but there is limited reproducibility across studies. In
The study utilized age matching and sex matching to reduce batch effects and improve data analysis. Different omic features were compared between matched pairs of children with autism spectrum disorder (ASD) and neurotypical children. The study performed benchmarking exercises and sensitivity
The study found that the high variability observed among datasets in the gut-brain axis analysis of autism spectrum disorder (ASD) could be attributed to experimental and laboratory-specific batch effects. The differential analysis showed a high degree of correlation within studies, supporting the
ASD-specific microbiome differences were detected in an age-matched and sex-matched cohort, but not in a sibling-matched cohort. Age and sex were significant confounders in both cohorts, but the age-matched and sex-matched cohort
Microbial log ratios constructed from differentially abundant microbes and cytokines showed a shift in microbial load between individuals with autism spectrum disorder (ASD) and neurotypical controls. There was overlap between ASD-enriched pathways in the microbiome and the
Longitudinal intervention studies provide stronger insights into causality. A re-analysis of a 2-year fecal matter transplant (FMT) study with 18 children with ASD showed significant improvements in autism symptoms after a 10-week course of treatment.
The study analyzed the gut-brain axis in individuals with autism spectrum disorder (ASD) and found that the metabolic profiles from the microbiome and human transcriptome showed a significant overlap in pathways expressed in the gut and brain. The analysis also revealed reduced
The study highlights the need to address model mis-specification issues and minimize confounding factors in order to infer causal mechanisms from population-scale studies on the gut-brain axis in autism spectrum disorder (ASD). The authors emphasize the potential for boosting statistical power
The study compared unrarefied data to rarefied data and found strong agreement in log fold changes. Simulation benchmarks also validated the model's ability to capture ground truth log fold changes. A comparison was made between different differential ranking methods, showing that
The study utilized a differential abundance methodology to analyze the FMT dataset. It matched pairs of timepoints and computed the differential abundance across each pair. A common set of taxa associated with controls was selected to make the differentials comparable. The model canceled out
Large-scale exome sequencing and neuroimaging studies have implicated both developmental and functional changes in the neurobiology of autism. Gastrointestinal disturbances are prevalent in individuals with autism spectrum disorder (ASD) and are associated with multiple factors. The gut microbi
This article references several studies and articles related to the gut-brain axis and its association with autism spectrum disorder (ASD). It highlights the importance of reproducibility, robustness, and generalizability in microbiome research. The management of batch
Several studies have analyzed the gut microbiome and its relationship to autism spectrum disorder (ASD). One study conducted in Ecuador found differences in gut microbiome, nutrition, and immune status between individuals with ASD and controls. Another study investigated the impact of dietary
Children with autism and their typically developing siblings have differences in the microbial profiles of their stool. These differences can affect gut physiology and behavior associated with autism. The Prevotella copri complex, which is underrepresented in Westernized populations, is one of
Several studies have investigated the relationship between the gut-brain axis and autism spectrum disorder (ASD). Metabolite profiles in the plasma, feces, and urine of individuals with ASD have been found to be altered. Amino acid dysregulation
This article discusses the gut-brain axis in relation to autism spectrum disorder (ASD). It references various studies that have identified molecular and microbial profiles associated with ASD. These studies include single-cell genomics, which identified cell type-specific molecular changes, and
The study examined the gut-brain axis in individuals with autism spectrum disorder (ASD) and found molecular and microbial profiles associated with the disorder. The research team used multi-level analysis to investigate the relationship between gut microbiota and ASD. They identified specific
This study on the gut-brain axis in individuals with autism spectrum disorder (ASD) was conducted by a collaborative team from various institutions around the world. The research aimed to analyze the molecular and microbial profiles associated with ASD. The authors developed a software
The authors of the study have various competing interests, but the remaining authors declare no competing interests. The study approach involved addressing challenges in metagenomic sequence data analysis, such as the lack of absolute abundance information and the presence of zero counts. The authors
Comparison of differentials obtained from 16S and SMS on the same samples from Dan et al across taxa observed in both datasets. Age differences between case-control matchings. Estimated microbial log-fold changes compared to ground truth microbial log-fold changes in household matched